姓名:乔爱君 性别:男 职称:研究员 学历:博士 电话:0760-85286866 电子邮件:qiaoaijun@simm.ac.cn 职务:课题组长 通讯地址:广东翠亨新区中瑞(欧)工业园健康医药示范区
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个人简历
乔爱君博士毕业于中国医学科学院&北京协和医学院(清华大学医学部),回国前担任美国阿拉巴马大学伯明翰分校生物工程系和糖尿病研究中心助理教授,目前担任中国科学院上海药物研究所和中科中山药物创新研究院研究员,博士生导师,课题组长(PI)。乔博士长期致力于发掘调控糖脂代谢的新分子和网络通路,并探究其对2型糖尿病、非酒精性脂肪肝、肥胖、动脉粥样硬化等代谢性疾病和心血管疾病发生发展的作用,为新药开发和治疗方案提供创新思路和试验基础。
研究领域
糖尿病、肥胖、非酒精性脂肪肝以及心血管疾病发病的分子机制研究及相关疾病创新药物的研发。
研究成果
乔爱君博士目前已发表原创SCI论文(包括接收)32篇(10篇IF≥10分),第一或通讯作者文章17篇(4篇IF≥10分),作为主编出版专著1部,出版编著1部(1章);获得中国科学院高层次引进人才、上海市高层次海外领军人才、中国科学院上海药物研究所高层次引进人才、美国心脏病学会职业发展奖等荣誉称号;兼任美国心脏病学会各类基金、美国密歇根州糖尿病中心基金、奥地利国家科学基金评审委员;担任PLOS ONE、Biology等杂志编委和Transl Res、FASEB J等杂志评审专家。
代表性论著(*:通讯作者)
1. Aijun Qiao*, Wenxia Ma, Huadong Li, Shiyue Xu, Eric Zhang, Jiawei Shi, Chan Boriboun, Junlan Zhou, Thanh Nguyen, Xin Tong, Lei Yin, Chunxiang Zhang, Yabing Chen, Jianyi Zhang, Gangjian Qin*. Hepatic Sam68 deficiency protects against hypercholesterolemia and atherosclerosis. (Circulation Research, 2024, Resubmitted)
2. Aijun Qiao#, Yuhua Wei#, Yanwen Liu, Asher Kahn-Krell, Lei Ye, Thanh Nguyen, Jianyi Zhang. Doxycycline-Mediated Control of Cyclin D2 Overexpression in Human-Induced Pluripotent Stem Cells. International Journal of Molecular Sciences, 2024, 25, 8714.
3. Xianghong Xie#, Mingyue Gao#, Heping Wang, Wei Zhao, Chunmei Li, Weihong Zhang, Jiahui Yang, Yinliang Zhang, Enhui Chen, Yanfang Guo, Zeyu Guo, Minglong Zhang, Ebenezeri Erasto Ngowi, Xiaoman Wang, Yinghan Zhu, Yiting Wang, Xiaolu Li, Hong Yao, Li Yan, Fude Fang, Meixia Li*, Aijun Qiao*, Xiaojun Liu*. LncRNA Snhg3 regulates hepatic glycogenesis in mouse under normal chow diet. The FASEB Journal, 2024, 38(15):e23880.
4. Xianghong Xie, Mingyue Gao, Wei Zhao, Chunmei Li, Weihong Zhang, Jiahui Yang, Yinliang Zhang, Enhui Chen, Yanfang Guo, Zeyu Guo, Minglong Zhang, Ebenezeri Erasto Ngowi, Heping Wang, Xiaoman Wang, Yinghan Zhu, Yiting Wang, Xiaolu Li, Hong Yao, Li Yan, Fude Fang, Meixia Li*, Aijun Qiao*, Xiaojun Liu*. LncRNA-Snhg3 Aggravates Hepatic Steatosis via PPARγ Signaling. eLife, 2024, 13:RP96988.
5. Aijun Qiao*, Wenxia Ma, Ying Jiang, Chaoshan Han, Baolong Yan, Junlan Zhou, Gangjian Qin*. Hepatic Sam68 regulates systemic glucose homeostasis and insulin sensitivity. International Journal of Molecular Sciences, 2022, 23(19), 11469.
6. Aijun Qiao*, Wenxia Ma, Jianxin Deng, Junlan Zhou, Chaoshan Han, Eric Zhang, Chan Boriboun, Shiyue Xu, Chunxiang Zhang, Chunfa Jie, Jeong-a Kim, Kirk Habegger, Hongyu Qiu, Ting C Zhao, Jianyi Zhang, Gangjian Qin*. Ablation of Sam68 in adult mice increases thermogenesis and energy expenditure. The FASEB Journal, 2021, 35(8): e21772.
7. Aijun Qiao, Junlan Zhou, Shiyue Xu, Wenxia Ma, Chan Boriboun, Teayoun Kim, Baolong Yan, Jianxin Deng, Liu Yang, Eric Zhang, Yuhua Song, Yongchao C. Ma, Stephane Richard, Chunxiang Zhang, Hongyu Qiu, Kirk Habegger, Jianyi Zhang, Gangjian Qin. Sam68 promotes hepatic gluconeogenesis via CRTC2. Nature Communications, 2021, 12(1):3340.
8. Aijun Qiao#, Xiongjie Jin#, Junfeng Pang, Demetrius Moskophidis, and Nahid F. Mivech. The transcriptional regulator of the chaperone response HSF1 controls hepatic bioenergetics and protein homeostasis. Journal of Cell Biology, 2017, 216(3):723-741. (Paper was selected by Journal as a Spotlight Paper and highlighted by another paper in the same Issue- http://jcb.rupress.org/content/early/2017/02/08/jcb.201701093?papetoc)
9. Aijun Qiao, Arineh Khechaduri, R. Kannan Mutharasan, Rongxue Wu, Varun Nagpal and Hossein Ardehali. MicroRNA-210 Decreases Heme Levels by Targeting Ferrochelatase in Cardiomyocyte. Journal of the American Heart Association, 2013, 2(2): e000121.
10.Aijun Qiao, Jichao Liang, Yaojun Ke, Chenghong Li, Ying Cui, Lian Shen, Huabing Zhang, Anfang Cui, Xiaojun Liu, Changzheng Liu, Yong Chen, Yi Zhu, Youfei Guan, Fude Fang, Yongsheng Chang. Mouse PNPLA3 Influences Systemic Lipid and Glucose Homeostasis. Hepatology, 2011, Aug; 54(2): 509-21.
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