2002-2006 南京理工大学-化工学院-生物工程专业(本科毕业)

2006-2012 南京理工大学-环境与生物工程学院-化学工程与技术(博士研究室毕业)

2012-2014 美国杰克逊实验室（Jackson Lab, Maine, US）-博士后研究员

2014-2022 新加坡科技研究局分子与细胞研究所(Institute of Molecular and Cell Biology (IMCB), The Agency for Science, Technology and Research (A*STAR), Singapore)-Senior Research Fellow

2022-今 中科中山药物创新研究院-研究员(课题组长)

1.人源化动物疾病模型
2.人源化药物靶点
3.mRNA和蛋白类药物

前期的研究成果包括:1.构建肝细胞癌-免疫双人源化小鼠模型。2.确定了HMGB1-TLR4-IL33-IL6-JAK2- STAT3信号通路在肝细胞癌发展中的重要作用。3.证实了光-P38-MK2-ROS-HIF1a/BMAL1-CXCR4信号通路 对免疫昼夜节律调控的影响。截止目前已接收和发表SCI论文18篇，其中以第一作者身份发表于Hepatology(2021),Gut(2018),Blood (2017)等国际知名杂志。

1. Zhao Y# (第一作者) ,Wang J,# Liu WN, Fong SY, Shuen TWH, Liu M, Harden S, Tan SY, Cheng JY, Tan WWS, Kok Yen Chan J, Chee CE, Lee GH, Toh HC, Lim SG, Wan Y, Chen Q. Analysis and validation of human targets and treatments using a hepatocellular carcinoma-immune humanized mouse model. Hepatology. 2021 Sep;74(3):1395-1410.(Original article)

2. Zhao Y (第一作者), Shuen TWH, Toh TB, Chan XY, Liu M, Tan SY, Fan Y,Yang H, Lyer SG, Bonney GK, Loh E, Chang KTE, Tan TC, Zhai W, Chan JKY, Chow EK, Chee CE, Lee GH, Dan YY, Chow PK, Toh HC, Lim SG, Chen Q. Development of a new patient-derived xenograft humanised mouse model to study human-specific tumour microenvironment and immunotherapy. Gut. 2018 Oct;67(10):1845-1854. (Original article). Highlight by editor (Poirier N, Vanhove B. Dynamic human immune and tumour cells cross-talk in PDX-humanised mice warrants checkpoint inhibitor cancer immunotherapies assessment. Gut. 2018 Oct;67(10):1753-1754.)

3. Zhao Y(第一作者), Liu M, Chan XY, Tan SY, Subramaniam S, Fan Y, Loh E, Chang KTE, Tan TC, Chen Q. Uncovering the mystery of opposite circadian rhythms between mouse and human leukocytes in humanized mice. Blood. 2017 Nov 2;130(18):1995-2005. (Regular article). Highlight as editor choice (Simón Méndez-Ferrer. Human and mouse leukocytes: different clockwork Blood 2017 130:1960-1961) 

4. Zhao Y(第一作者), Zhang Y, Zhou M, Wang S, Hua Z, Zhang J. Loss of mPer2 increases plasma insulin levels by enhanced glucose-stimulated insulin secretion and impaired insulin clearance in mice. FEBS Lett. 2012. 586(9):1306-11.

5. Zhao Y(第一作者), Zhang Y, Wang S, Hua Z, Zhang J. The clock gene Per2 is required for normal platelet formation and function. Thromb Res.2011. 127(2):122-30.

6.Zhao Y#, Cheng R#, Zhao Y # ,Ge W, Yang Y, Ding Z, Xu X, Wang Z, Wu Z, Zhang J. Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid. J Biol Chem. 2021 Oct;297(4):101166.

7. Sun Q#, Zhao Y#, Yang Y, Yang X, Li M, Xu X, Wen D, Wang J, Zhang J. Loss of the clock protein PER2 shortens the erythrocyte life span in mice. J Biol Chem. 2017 Jul 28;292(30):12679-12690.