教育经历：

2008—2012 四川大学, 理学学士，药学

2012—2017 中国科学院上海药物研究所, 理学博士，药物化学

工作经历：

2017—2018 美国 H. Lee Moffitt Cancer Center and Research Institute，博士后

2018—2021 美国 Baylor College of Medicine，博士后

2021—至今 中科中山药物创新研究院和中国科学院上海药物所副研究员、青年课题组长

针对肿瘤、免疫和病毒感染等临床未满足的疾病需求进行新药开发研究，同时探索类药性杂环小分子合成新方法，并将其应用于药物发现过程。

近年来主要从事抗肿瘤，抗病毒以及神经精神类疾病等小分子药物的合理设计、合成及药理活性研究；同时开展新颖的类药性杂环合成方法学研究，主要目的是构建特色类药性杂环化合物库，并将其应用于药物发现过程中。相关研究成果已发表在知名学术期刊ACS Catalysis、Chem Catalysis、Acta Pharmaceutica Sinica B、Green Chemistry、Journal of Medicinal Chemistry、Organic Letters、Organic Chemistry Frontiers、European Journal of Medicinal Chemistry等。现累计以第一作者和通讯作者发表SCI论文26篇。Google Scholar引用次数960余次，H-index = 20。

1. Shiping Zhan,# Yingying Zhang,# Tian Cao,# Ruirui Yang,# Qiang Wang, Lin Huang, Rongrong Cui, Jie Yu, Haifang Meng, Yitian Wang, Sulin Zhang,* Mingyue Zheng,* Xiaowei Wu*. Journal of Medicinal Chemistry, 2024, accepted.

2. Xueqing Liu,# Sijia Shi,# Wenqian Ding, Zhiyue He, Yu Shen, Yong Nian,* and Xiaowei Wu*. Organic Letters, 2024, 26, 5136-5140.

3. Yan Wang,# Sijia Shi,# Wei Zhang, Yong Nian*, and Xiaowei Wu*. Rhodium-catalyzed diastereoselective C-H activation/[4+2] annulation of a,b-unsaturated amides with bicyclic alkenes. Organic Letters, 2024, 26, 483-487.

4. Hao Wang,# Yidi Li,# Lin Huang,# Huiying Xu,# Yukun Jiao,# Zhi Zhou, Zhenhao Tang, Feifei Fang, Xiaoxue Zhang, Kan Ding, Wei Yi*, Hong Liu*, Xiaowei Wu*, and Yu Zhou*. The Synthesis of Spirocyclopropane Skeletons Enabled by Rh(III)-Catalyzed Enantioselective C-H Activation/[4+2] Annulation. Chem Catalysis, 2023, 3, 100822.

5. Yidi Li,# Huiying Xu,# Zhi Zhou*, Lin Huang, Zhenhao Tang, Wei Yi* and Xiaowei Wu*. An unusual four-step cascade reaction for accessing furo[3,4-c]pyridine-1,4-diones via rhodium catalysis. Organic Chemistry Frontiers, 2023, 10, 4658-4664.

6. Yidi Li,# Huiying Xu,# Lin Huang,# Zhi Zhou*, Zhenhao Tang, Haifang Meng, Wei Zhang, Wei Yi*, Xiaowei Wu*. Rhodium-catalyzed Regioselective C-H Activation/Lossen Rearrangement/Annulation for the Green Synthesis of Trisubstituted 2-Pyridones. Organic Chemistry Frontiers, 2023, 10, 3000-3009.

7. Haifang Meng,# Huiying Xu,# Zhi Zhou,# Zhenhao Tang, Yidi Li, Yu Zhou*, Wei Yi*, Xiaowei Wu*. Recyclable rhodium-catalyzed C-H activation/[4+2] annulation with unconventional regioselectivity at ambient temperature: experimental development and mechanistic insight. Green Chemistry, 2022, 24, 7012-7021.

8. Xiaowei Wu,# Mengdi Dai,# Rongrong Cui,# Yulan Wang, Chunpu Li, Xia Peng, Jihui Zhao, Bao Wang, Yang Dai, Dan Feng, Tianbiao Yang, Hualiang Jiang, Meiyu Geng, Jing Ai*, Mingyue Zheng*, Hong Liu*. Design, Synthesis and pharmacological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors. Acta Pharmaceutica Sinica B. 2021, 11, 781-794.

9. Fei Zhao*,# Zhi Zhou,# Yangbin Lu,# Jin Qiao, Xiaoning Zhang, Xin Gong, Siyu Liu, Shuang Lin, Xiaowei Wu*, Wei Yi*. Chemo-, Regio-, and Stereoselective Assembly of Polysubstituted Furan-2(5H)-ones Enabled by Rh(III)-Catalyzed Domino C-H Alkenylation/Directing Group Migration/Lactonization: A Combined Experimental and Computational Study. ACS Catalysis, 2021, 11, 13921-13934.

10. Xiaowei Wu,# Yangbin Lu,# Jin Qiao, Wenhao Dai, Xiuwen Jia, Hangcheng Ni, Xiaoning Zhang, Hong Liu*, and Fei Zhao*. Rhodium(III)-Catalyzed C–H Alkenylation/Directing Group Migration for the Regio- and Stereoselective Synthesis of Tetrasubstituted Alkenes. Organic Letters, 2020, 22, 9163-9168.

11. Yulan Wang,# Yang Dai,# Xiaowei Wu,# Fei Li, Bo Liu, Chunpu Li, Qiufeng Liu, Yuanyang Zhou, Bao Wang, Mingrui Zhu, Rongrong Cui, Xiaoqin Tan, Zhaoping Xiong, Jia Liu, Minjia Tan, Yechun Xu, Mei-Yu Geng, Hualiang Jiang, Hong Liu*, Jing Ai*, Mingyue Zheng*. The Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as Novel Covalent FGFR Inhibitors by Rational Drug Design. J. Med. Chem. 2019, 62, 7473-7488.

12. Xiaowei Wu, Haitao Ji*. Ruthenium(II)-Catalyzed Regio- and Stereoselective C−H Allylation of Indoles with Allyl Alcohols. Organic Letters, 2018, 20, 2224-2227.

13. Xiaowei Wu, Bao Wang, Shengbin Zhou, Yu Zhou*, Hong Liu*. Ruthenium-Catalyzed Redox-Neutral [4+1] Annulation of Benzamides and Propargyl alcohols via C-H Bond Activation. ACS Catalysis, 2017, 7, 2494-2499.