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李媛媛

姓名:李媛媛 性别: 职称:研究员 学历:博士 电话:0760-85286866 电子邮件:liyuanyuan@simm.ac.cn 职务:课题组长 通讯地址:广东翠亨新区中瑞(欧)工业园健康医药示范区

  • 个人简历

    2004年本科毕业于华中科技大学同济医学院,同年进入上海药物所硕博联读,2010年获得上海药物所药理学博士。随后赴美留学,先后在约翰霍普金斯大学医学院,东北俄亥俄医科大学和贝勒医学院从事博士后研究,主要开展代谢性疾病,例如糖尿病,非酒精性脂肪肝病及动脉粥样硬化的致病机理研究和创新药物开发。2020年经过上海药物研究所引进,任上海药物研究所研究员,课题组长;中科中山药物创新研究院研究员,课题组长。

  • 研究领域

    代谢性疾病,例如糖尿病,非酒精性脂肪肝病及动脉粥样硬化的致病机理研究和创新药物开发

  • 研究成果

    李媛媛长期从事代谢性疾病,例如非酒精性脂肪肝病,糖尿病以及其并发症动脉粥样硬化等的病理机制研究以及创新药物开发。实验室主要致力于发现新颖的致病信号通路并阐明其病理机制,同时在此过程中寻找潜在的治疗靶点进行创新药物研发。基础研究方面,目前已发表学术论文25篇(含9 篇一作)。以一作发表于代谢领域权威杂志Nature Metabolism, Hepatology, Arterioscler Thromb Vasc Biol等,以合作者发表于Cell Metabolism, Nature Communications, Diabetes等领域权威杂志。发表文章得到Nature Reviews Endocrinology, Hepatology, Diabetes 等杂志的高度评价,且得到Faculty 1000 肝病领域权威专家的推荐。
    文章总引用超过1000次,H-index 18。药物研发方面,作为主要参与人开发了10多个新颖有潜力的二型糖尿病小分子化合物,申请中国专利一项,其中有些候选药物已经拿到临床批件,实现成果转化。2010年获得上海市优秀博士毕业生;2014年获得美国心血管会议优秀口头报告奖;2016年获得美国肝病会议杰出学术海报奖和优秀年轻学者旅行奖;2010年至2020年参与承担多项美国国立卫生研究院代谢性疾病R01研究基金;2020年作为主持人承担美国国立卫生研究院T32肝脏方向培训基金。

  • 代表性论著(*:通讯作者)

    1. Yanyong Xu#, Yuanyuan Li#, Kavita Jadhav#, Xiaoli Pan, Yingdong Zhu, Shuwei Hu,  Shaoru Chen, Liuying Chen, Yong Tang, Helen H Wang, Ling Yang, David Q-H Wang, Liya Yin, Yanqiao Zhang*. Hepatocyte ATF3 protects against atherosclerosis by regulating HDL and bile acid metabolism. Nature Metabolism, 2021, 3(1):59-74(# Co-first author)

    2. Yuanyuan Li#, Yanyong Xu#, Kavita Jadhav, Liya Yin and Yanqiao Zhang*. Hepatic forkhead box protein A3 regulates ApoA I expression, cholesterol efflux and atherogenesis. Arteriosclerosis, Thrombosis, and Vascular Biology, 2019, 39(8):1574-1587(# Co-first author)

    3. Yuanyuan Li, Munaf Zalzala, Kavita Jadhav, Yang Xu, Takhar Kasumov, Liya Yin and Yanqiao Zhang*. Carboxylesterase 2 Prevents Liver Steatosis by Modulating Lipolysis, ER stress and Lipogenesis and is regulated by Hepatocyte Nuclear Factor 4 Alpha in Mice. Hepatology, 2016, 63:1860-1874  此研究内容获得2016AASLD肝病会议大会杰出海报奖与优秀年轻学者旅行奖

    4. Jiesi Xu #, Yuanyuan Li #, Wei Dong Chen #, Yang Xu #, Liya Yin, Xuemei Ge, Kavita Jadhav, Luciano Adorini, and Yanqiao Zhang*. Hepatic Carboxylesterase 1 Is Essential for Both Normal and Farnesoid X Receptor Controlled Lipid Homeostasis. Hepatology, 2014, 59:1761-1771 (# Co-first author) 被同期Hepatology 高度评价,Faculty of 1000 推荐

    5. Yuanyuan Li, Kavita Jadhav, and Yanqiao Zhang*. Bile acid receptors in non-alcoholic fatty liver disease. Biochem Pharmacol, 2013, 86(11):1517-24

    6. Yuan-Yuan Li#, Li-Fang Yu#, Li-Na Zhang, Bei-Ying Qiu, Ming-Bo Su, Fang Wu, Tao Pang, Min Gu, Wei Zhang, Da-Kai Chen,Wei-Ping Ma, Jing-Ya Li*, Fa-Jun Nan*, Jia Li*. Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice. Toxicol Appl Pharm, 2013, 273(2):325-34 (# Co-first author)

    7. Li-Fang Yu#, Yuan-Yuan Li#, Ming-Bo Su, Mei Zhang , Wei Zhang , Li-Na Zhang , Tao Pang , Run-Tao Zhang , Bing Liu , Jing-Ya Li*, Jia Li*, and Fa-Jun Nan*. Development of Novel Alkene Oxindole Derivatives As Orally Efficacious AMP-Activated Protein Kinase Activators. ACS Med. Chem. Lett., 2013, 4 (5): 475–480 (# Co-first author)

    8. Linrong Zhu#, Yuanyuan Li#, Qiu Ling, Mingbo Su, Xin Wang, Chunmei Xia, Yi Qu, Jingya Li, Jia Li*, Bin Xiong*, Jingkang Shen*. Design and Synthesis of 4-(2,4,5-Trifluorophenyl)butane-1,3-diamines as Dipeptidyl Peptidase IV Inhibitors. ChemMedChem, 2013, 8(7):1104-16 (# Co-first author)

    9. Zhang Liu#, Qian Chai #, Yuanyuan Li #, Qiang Shen, Lanping Ma*, Lina Zhang, Xin Wang, Li Sheng, Jingya Li, Jia Li*, Jingkang Shen. Discovery of novel PTP1B inhibitors with antihyperglycemic activity. Acta Pharmacologica Sinica, 2010, 31:1005–1012 (# Co-first author)

    10. Michael L. Multhaup, Marcus M. Seldin, Andrew E. Jaffe, Xia Lei, Henriette Kirchner, Prosenjit Mondal, Yuanyuan Li, Varenka Rodriguez, Alexander Drong, Mehboob Hussain, Cecilia Lindgren, Mark McCarthy, Erik Näslund, Juleen R. Zierath, G. William Wong, Andrew P. Feinberg*. Mouse-Human Experimental Epigenetic Analysis Unmasks Dietary Targets and Genetic Liability for Diabetic Phenotypes. Cell Metabolism, 2015, 21(1):138-49

    11. Yang Xu#, Munaf Zalzala#, Jiesi Xu, Yuanyuan Li, Liya Yin, Yanqiao Zhang*. A metabolic stress-inducible miR-34a-HNF4α pathway regulates lipid and lipoprotein metabolism. Nature communications, 2015, 6:7466


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