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李威

姓名:李威 性别: 职称:副研究员 学历:博士研究生 电话:0760-85286866 电子邮件:liwei1@simm.ac.cn 职务:课题组长 通讯地址:广东翠亨新区中瑞(欧)工业园健康医药示范区

  • 个人简历

    教育经历:
    2011.09-2015.06,广州中医药大学,理学学士
    2015.09-2020.06,中山大学,理学博士,生药学,导师:尹胜 教授
    工作经历:
    2020.07-2022.07,中山大学药学院,博士后,合作导师:卜宪章 教授
    2022.08-至今,中科中山药物创新研究院,副研究员、青年课题组长

  • 研究领域

    基于药用资源活性新颖分子的发现;基于活性分子的结构修饰及构效关系研究

  • 研究成果

    构建了液质联用和特征核磁指纹图谱相结合的高效追踪分离体系,对10余种大戟科为主的药用植物开展了系统的化学成分研究,获得了系列结构新颖的活性分子,并建立了骨架多样性的大戟科二萜化合物库。在Nat. Prod. Rep.、Org. Lett.、J. Nat. Prod. 等本领域专业期刊杂志上发表SCI论文34篇,其中以第一或通讯作者身份发表14篇。主持国家自然科学基金青年项目和中国博士后科学基金面上项目各1项。

  • 代表性论著(*:通讯作者)

    1) Wei Li, Gui-Hua Tang and Sheng Yin*. Selaginellins from the genus Selaginella: isolation, structure, biological activity, and synthesis. Natural Product Reports, 2021, 38, 822–842.

    2) Wei Li, Rui-Min Wang, Yue-Hua Pan, Ying-Yuan Zhao, Fang-Yu Yuan, Dong Huang, Gui-Hua Tang, Hui-Chang Bi, and Sheng Yin*. Crotonpenoids A and B, two highly modified clerodane diterpenoids with a tricyclo[7.2.1.02,7]dodecane core from Croton yanhuii: isolation, structural elucidation, and biomimetic semisynthesis. Organic Letters, 2020, 22, 4435−4439.

    3) Wei Li,# Ya-Qi Tang,# Jun Sang, Run-Zhu Fan, Gui-Hua Tang, and Sheng Yin*. Jatrofolianes A and B: two highly modified lathyrane diterpenoids from Jatropha gossypiifolia. Organic Letters, 2020, 22, 106−109.

    4) Wei Li, Ya-Qi Tang, Shi-Xin Chen, Gui-Hua Tang, Li-She Gan, Chan Li, Yong Rao, Zhi-Shu Huang, and Sheng Yin*. Euphorhelipanes A and B, triglyceride-lowering Euphorbia diterpenoids with a bicyclo[4.3.0]nonane core from Euphorbia helioscopia. Journal of Natural Products, 2019, 82, 412−416.

    5) Wei Li, Li Rao, Yu Liu, Qian He, Yue Fan, Yun-Xia You, Yu Su, Feng Hu, You-Kai Xu, Bin Lin, Sheng Yin, Chuan-Rui Zhang*. (±)-Meliviticines A and B: Rearranged prenylated acetophenone derivatives from Melicope viticina and their antimicrobial activity. Bioorganic Chemistry, 2019, 90, 103099.

    6) Wei Li, Yi-Hong Zou, Man-Xi Ge, Lan-Lan Lou, Yun-Shao Xu, Abrar Ahmed, Yun-Yun Chen, Jun-Sheng Zhang, Gui-Hua Tang and Sheng Yin*. Biscembranoids and cembranoids from the soft coral Sarcophyton elegans. Marine Drugs, 2017, 15, 85.

    7) Wei Li, Jun-Sheng Zhang, Jia-Luo Huang, Min-Hong Jiang, You-Kai Xu, Abrar Ahmed, Sheng Yin and Gui-Hua Tang*. New prenylated coumarins from the stems of Toddalia asiatica. RSC Advances, 2017, 7, 31061-31068.

    8) Wei Li,# Lan-Lan Lou,# Jian-Yong Zhu, Jun-Sheng Zhang, An-An Liang, Jing-Mei Bao, Gui-Hua Tang*, Sheng Yin. New lanostane-type triterpenoids from the fruiting body of Ganoderma hainanense. Fitoterapia, 2016, 115, 24–30.

    9) Wei Li,# Gui-Hua Tang,# Lin Chen, Ya-Qi Tang, You-Kai Xu, Bo Liu* and Sheng Yin*. New pyridocarbazole alkaloids from Strychnos nitida. Natural Product Research, 2018, 32, 1532–1536.

    10) Yao-Hao Xu,# Wei Li,# Yong Rao, Zhi-Shu Huang, and Sheng Yin*. Pyridocarbazole alkaloids from Ochrosia borbonica: lipid-lowering agents inhibit the cell proliferation and adipogenesis of 3T3-L1 adipocyte via intercalating into supercoiled DNA. Chinese Journal of Natural Medicines, 2019, 17, 663-671.

    11) Rong Hu,# Jia-Luo Huang,# Fang-Yu Yuan, Xun Wei, Ming-Feng Zou, Gui-Hua Tang, Wei Li*, and Sheng Yin*. Crotonianoids A-C, three unusual tigliane diterpenoids from Croton tiglium and their anti-prostate cancer activity. Journal of Organic Chemistry, 2022, 87, 9301–9306.

    12) Ming-Feng Zou,# Yue-Hua Pan,# Rong Hu, Fang-Yu Yuan, Dong Huang, Gui-Hua Tang, Wei Li*, and Sheng Yin*, Highly modified nor-clerodane diterpenoids from Croton yanhuii. Fitoterapia, 2021, 153 104979.

    13) Zhao Yin, Xing-Lin Xie, Jiao Yuan, Yao Zhang, and Wei Li*. Two new ent-abietane diterpenoids from Euphorbia helioscopia. Journal of Asian Natural Products Research, 2020, 22, 632–638.

    14) Xing-Lin Xie, Guo-Hua Ye, Jun-Juan Xue, Tong Su, Gui-Hua Tang, Wei Li*, and Sheng Yin*. A new prenylated coumarin and a new anthranilamide derivative from Evodia lepta. Journal of Asian Natural Products Research, 2020, 22, 413417.

    15) Jun Sang, Wei Li, Hong-Juan Diao, Run-Zhu Fan, Jia-Luo Huang, Lu Gan, Ming-Feng Zou, Gui-Hua Tang, and Sheng Yin*, Jolkinolide B targets thioredoxin and glutathione systems to induce ROS-mediated paraptosis and apoptosis in bladder cancer cells. Cancer Letters, 2021, 509, 13-25.

    16) Lan-Lan Lou, Wei Li, Bin-Hua Zhou, Lin Chen, Han-Zhuang Weng, Yi-Hong Zou, Gui-Hua Tang, Xian-Zhang Bu, Sheng Yin*. (+)-Isobicyclogermacrenal and spathulenol from Aristolochia yunnanensis alleviate cardiac fibrosis by inhibiting transforming growth factor β/small mother against decapentaplegic signaling pathway. Phytotherapy Research, 2019, 33, 214–223.

    17) Fu-Qiang Ni, Shu-Qi Wu, Wei Li, Qingjiang Li,* and Sheng Yin*. Stereoselective construction of the methylcyclopentane core of peditithins B−H with five continuous stereocenters. Organic Letters, 2020, 22, 93609364.

    18) Run-Zhu Fan,# Lin Chen,# Tong Su, Wei Li, Jia-Luo Huang, Jun Sang, Gui-Hua Tang, and Sheng Yin*. Discovery of 8,9-seco-ent-kaurane diterpenoids as potential leads for the treatment of triple-negative breast cancer. Journal of Medicinal Chemistry, 2021, 64, 9926−9942.

    19) Jianyong Zhu,# Ruimin Wang,# Lanlan Lou, Wei Li, Guihua Tang, Xianzhang Bu*, and Sheng Yin*. Jatrophane diterpenoids as modulators of P‑glycoprotein-dependent multidrug resistance (MDR): advances of structure−activity relationships and discovery of promising MDR reversal agents. Journal of Medicinal Chemistry, 2016, 59, 6353–6369.

    20) Dong Huang,# Rui-Min Wang,# Wei Li, Ying-Yuan Zhao, Fang-Yu Yuan, Xue-Long Yan, Ye Chen, Gui-Hua Tang, Hui-Chang Bi,* and Sheng Yin*. Lathyrane diterpenoids as novel hPXR agonists: isolation, structural modification, and structure−activity relationships. ACS Medicinal Chemistry Letters, 2021, 12, 1159−1165.