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周子凯

姓名:周子凯 性别: 职称:研究员 学历:博士 电话:0760-85286866 电子邮件:zhouzikai@simm.ac.cn 职务:课题组长 通讯地址:广东翠亨新区中瑞(欧)工业园健康医药示范区

  • 个人简历

    周子凯,研究员、课题组长。毕业于加拿大多伦多大学医学院生理学系/多伦多儿童医院,获神经科学博士学位。长期从事脑疾病的病理机制研究及相应疗法研发。2020年加入中科中山药物创新研究院。曾任上海交通大学医学院附属精神卫生中心研究员、博导;东南大学生命科学研究院副研究员、博导。主要工作方向为神经精神疾病的病理机制研究及相应的生物技术药物研发。已有成果发表论文28篇,包括Nature Neuroscience (2021, 2018)、Journal of Cell BiologyeLifeJouranl of NeuroscienceCerebral CortexNeuropharmacology等;主持国家自然科学基金等国家级项目4项;获得2项国家发明专利授权;入选上海市优秀学术带头人。

  • 研究领域

    细胞和重组蛋白等创新生物技术药物研发。

  • 研究成果

    建立新型疾病模型,采用神经生物学、免疫学、生物信息学等技术方法解析致病机制,发掘药物靶点,研发相应的生物技术药物。已有成果发表论文28篇,包括Nature Neuroscience (2021, 2018)、Journal of Cell Biology、 eLife、Jouranl of Neuroscience、Cerebral Cortex、Neuropharmacology等一流期刊。获得两项国家发明专利授权;主持4项国家自然科学基金等国家级项目;入选上海市优秀学术带头人。

  • 代表性论著(*:通讯作者)

    1. Xu Z#, Zhang X#, Chang H#, Kong Y, Ni Y, Ran Liu, Zhang X, Hu Y, Yang Z, Hou M, Mao R, Liu WT, Du Y, Yu S, Wang Z, Ji M*, Zhou Z*.  Rescue of maternal immune activation-induced behavioral abnormalities in adult mouse offspring by pathogen-activated maternal Treg cells. Nature Neuroscience. 2021 Apr.15. doi: 10.1038/s41593-021-00837-1

    2. Mao R#, Zhang X#, Kong Y, Wu S, Huo HQ, Kong Y, Wang Z, Liu Y*, Jia Z*, Zhou Z*.  Transcriptome Regulation by Oncogenic ALK Pathway in Mammalian Cortical Development Revealed by Single-Cell RNA Sequencing. Cerebral Cortex. 2021 Apr 1:bhab058. doi: 10.1093/cercor/bhab058.

    3. Zhang X*, Kong Y, He G, Zhou Z*.  Neonatal exposure to ketamine disrupts developmental synapse unsilencing and predisposes adult mice for stressor-evoked anxiety. Neuropharmacology. 2020 Dec 1;180:108300.

    4. Zhou Z#, Liu A#, Xia S#, Leung C#, Qi J, Meng Y, Xie W, Park P, Collingridge G*, and Jia Z*.  The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning. Nature Neuroscience. 2018 Jan;21(1):50-62.

    5. Yang X#, He G#, Zhang X, Chen L, Kong Y, Xie W, Jia Z, Liu WT*, Zhou Z*. Transient inhibition of LIMKs significantly attenuated central sensitization and delayed the development of chronic pain. Neuropharmacology. 2017 Oct;125:284-294.

    6. He G#, Yang X#, Wang G, Qi J, Mao R, Wu Z, Zhou Z*. Cdk7 is required for activity-dependent neuronal gene expression, long-lasting synaptic plasticity and long-term memory. Frontiers in Molecular Neuroscience. 2017 Nov 7;10:365.

    7. Xia S#, Zhou Z#, Leung C, Zhu Y, Pan X, Qi J, Morena M, Hill MN*, Xie W*, Jia Z*. p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus. eLife. 2016 Jun 14;5.

    8. Liu A#, Zhou Z#, Dang R, Zhu Y, Qi J, He G, Leung C, Pak D, Jia Z*, Xie W*. Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization. Journal of Cell Biology. 2016 Feb 15; 212(4):449-63. (COVER STORY with COMMENTARY)

    9. Li Y#, Zhou Z#, Zhang X, Tong H, Li P, Zhang ZC, Jia Z, Xie W*, Han J*. Drosophila neuroligin 4 regulates sleep through modulating GABA transmission. The Journal of Neuroscience. 2013, 33(39):15545-54

    10. Zhou Z, Hu J, Passafaro M, Xie W, Jia Z*. GluA2 (GluA2) regulates metabotropic glutamate receptor-dependent long-term depression through N-cadherin-dependent and cofilin-mediated actin reorganization. The Journal of Neuroscience. 2011, 31(3), 819-833

    Huang W#, Zhou Z#, Asrar S, Henkelman M, Xie W, Jia Z*. p21-activated kinases 1 and 3 control brain size through coordinating neuronal complexity and synaptic properties. Molecular and Cellular Biology. 2011 31(3), 388-403, (with COMMENTARY)